Breast Pathology

Pathology of the Breast

FIBROCYSTIC CHANGES (FCC) are a group of alterations in the female breast ranging from harmless to those associated with an increased risk of breast carcinoma. Some of these changes (stromal fibrosis and microcysts or macrocysts) produce palpable lumps. FCC are in essence an exaggeration and distortion of the cyclic breast changes that occur normally in the menstrual cycle. Traditionally, these...

The Network of Antigen-Antibody Reactions in Adult Women with Breast Cancer or Benign Breast Pathology or without Breast Pathology

The Immunoglobulin G (IgG) antibody response to different protein antigens of the mammary ductal carcinoma by adult women affected by Breast Cancer (BC) distinguishes at least 103 proteins that differ in their molecular weights (MW). The IgG producing cell clones (nodes) coexist with each other in each individual organism and share energy resources among themselves, as well as factors that cont...

Surgical and Clinical Pathology of Breast Diseases

Current issues in diagnostic breast pathology.

On behalf of the NHS Breast Screening Programme Pathology Coordinating Group we present recommendations for terminology and diagnostic criteria for a number of key areas of practice in breast pathology where terminology can be confusing and where accurate communication will ensure appropriate clinical management. These recommendations cover columnar cell lesions and the spectrum of changes that...

The Pathology of Hereditary Breast Cancer

Several studies have demonstrated that familial breast cancers associated with BRCA1 or BRCA2 germline mutations differ in their morphological and immunohistochemical characteristics. Cancers associated with BRCA1 are poorly differentiated infiltrating ductal carcinomas (IDCs) with higher mitotic counts and pleomorphism and less tubule formation than sporadic tumours. In addition, more cases wi...